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Medchemexpress LLC PF-04957325 | 1305115-80-3 | C14H15F3N8OS | 5 MG
Supplier: Medchemexpress LLC HY154265MG
PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM for PDE8A and 0.3 nM for PDE8B. It inhibits breast cancer cell migration and greatly potentiates steroidogenesis in WT adrenal cells.
- Highly potent and selective PDE8 inhibitor
- IC50s of 0.7 nM for PDE8A and 0.3 nM for PDE8B
- Inhibits breast cancer cell migration
- Potentiates steroidogenesis in WT adrenal cells
- Increases steroid production in WT Leydig cells or MA10 cells
- Synergistically potentiates steroid production with rolipram
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