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Cayman Chemical PF-05190457, Purity: ≥95%, CAS: 1334782-79-4, 5 mg
SDP

Catalog No. 502943514
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An inverse agonist of GHS-R; selectively binds to GHS-R (Ki = 4.37 nM) over M2 mAChRs (Ki = 1,950 nM) and 5-HT2B receptors (IC50 = 3,700 nM); increases glucose-induced insulin secretion in primary human pancreatic islets at 1 µM; potentiates GLP-1-induced intracellular calcium levels in isolated dispersed rat islets at 100 nM; increases ex vivo vagal nerve firing rate in rats when administered intragastrically (EC50 = 10.7 nM)

Catalog No. 50-294-3514 Supplier Cayman Chemical Supplier No. 401425 MG
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An inverse agonist of GHS-R; selectively binds to GHS-R (Ki = 4.37 nM) over M2 mAChRs (Ki = 1,950 nM) and 5-HT2B receptors (IC50 = 3,700 nM); increases glucose-induced insulin secretion in primary human pancreatic islets at 1 µM; potentiates GLP-1-induced intracellular calcium levels in isolated dispersed rat islets at 100 nM; increases ex vivo vagal nerve firing rate in rats when administered intragastrically (EC50 = 10.7 nM)

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