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Apexbio Technology LLC PF-05212384 (PKI-587) 1197160-78-3 25mg
Supplier: Apexbio Technology LLC B217925
PF-05212384 (PKI-587) is a dual inhibitor targeting both phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) It exhibits potent inhibitory activity targeting PI3K isoforms with IC50 values of 0 4 nM 6 nM 8 nM and 6 nM respectively as well as mTOR at 1 4 nM Furthermore PF-05212384 effectively suppresses mutant PI3K forms including the H1047R and E545K mutations In cell-based assays this compound inhibits PI3K/mTOR signaling pathways evidenced by decreased phosphorylation of downstream proteins Akt GSK3 eNOS and PRAS40 PF-05212384 has demonstrated anti-tumor effects in various xenograft tumor models thus serving as a useful tool molecule for investigating PI3K/mTOR pathway functions and related oncology studies
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