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Medchemexpress LLC Pf-06446846 hydrochloride | 1632250-50-0 | 99.4% | 10 MM 1 ML
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Supplier:  Medchemexpress LLC HY120088A10MM 1ML

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Pf-06446846 hydrochloride is the hydrochloride salt of a small-molecule inhibitor that selectively inhibits translation of PCSK9 by inducing ribosomal stalling; supplied as a 10 mM solution in DMSO for research use. It reduces PCSK9 secretion in Huh7 cells (IC50 ≈ 0.3 μM).

  • Hydrochloride salt form, soluble in DMSO and water.
  • Targets PCSK9 and inhibits its translation via ribosomal stalling.
  • Demonstrated activity in cell assays (Huh7 cells; IC50 ~0.3 μM).
  • Supplied as a 10 mM solution in DMSO, 1 mL vial.
  • Molecular weight 470.35; formula C22H21Cl2N7O.
  • Storage: solid at 4°C; in solvent, -80°C (up to 2 years) or -20°C (up to 1 year).

Catalog No. 50-002-31863


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