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Medchemexpress LLC PF-06815345 hydrochloride | 2334434-49-8 | 98.15% | 634.49 | 10 MG
Supplier: Medchemexpress LLC HY112598A10MG
PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13.4 μM. It significantly decreases the PCSK9 level in vivo in mouse. A clinical trial (NCT02654899) sponsored by Pfizer for Hypercholesterolemia started in November 2015 and is in Phase 1.
- Potent PCSK9 inhibitor with an IC50 of 13.4 μM.
- Significantly decreases PCSK9 levels in vivo.
- Shows CLint values of <82.9 μL/min/mg in human enterocytes and 97.6 μL/min/mg in human hepatocytes.
- Lowers plasma PCSK9 by 72% at 500 mg/kg in a humanized PCSK9 mouse model.
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