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Apexbio Technology LLC PF-2545920 1292799-56-4 200mg
Supplier: Apexbio Technology LLC A4325200
PF-2545920 is a small-molecule inhibitor targeting phosphodiesterase 10A (PDE10A) It is designed to selectively inhibit PDE10A thereby modulating neuronal cAMP and cGMP signaling within cortico-striato-thalamic circuits PF-2545920 exerts its biological activity primarily through selective inhibition of PDE10A In in vitro studies PF-2545920 demonstrates potent inhibitory activity with an IC50 value of 0 37 nM In experimental mouse models it increases striatal cGMP levels at doses around 1 mg/kg Based on these pharmacological properties PF-2545920 holds research potential in the investigation of PDE10A-associated neurobiology and neuropsychiatric conditions such as schizophrenia
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