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Apexbio Technology LLC PF-3758309 898044-15-0 10mM (in 1mL DMSO)
SDP

Supplier:  Apexbio Technology LLC A37165.1

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PF-3758309 (CAS 898044-15-0) is a selective ATP-competitive inhibitor of p21-activated kinase 4 (PAK4) a serine/threonine kinase involved in cytoskeletal reorganization and cellular signaling mediated by Cdc42-GTP and JNK-GTP interactions PF-3758309 inhibits phosphorylation of PAK4 substrates (e g GEF-H1 IC50 1 3 nM) and suppresses PAK4-mediated anchorage-independent growth In xenograft tumor models (HCT116 A549) oral administration of PF-3758309 significantly reduced tumor growth demonstrating its utility in research investigating PAK-dependent oncogenic pathways

Catalog No. 50-000-64016


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