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Medchemexpress LLC PF-543 Citrate | 1415562-83-2 | C33H39NO11S | 1 ML
Supplier: Medchemexpress LLC HY15425A10MM/1ML
PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible, and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. It demonstrates over 100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. It is known to induce apoptosis, necrosis, and autophagy.
- Potent, selective, reversible, and sphingosine-competitive SPHK1 inhibitor
- IC50 of 2 nM and Ki of 3.6 nM for SPHK1
- Over 100-fold selectivity for SPHK1 over SPHK2
- Effective inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM
- Induces apoptosis, necrosis, and autophagy
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