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Apexbio Technology LLC PF-670462 950912-80-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A37195.1
PF-670462 (CAS 950912-80-8) is a selective inhibitor of casein kinase 1 (CK1) isoforms CK1 and CK1 serine/threonine kinases involved in circadian rhythm regulation It exhibits inhibitory activity toward CK1 and CK1 with IC50 values of approximately 80 nM and 13 nM respectively In cellular models co-transfected with GFP-tagged PER3 and human CK1 PF-670462 blocks nuclear translocation of PER3 In primary fibroblasts from wild-type mice it dose-dependently prolongs circadian cycle length PF-670462 serves as a useful chemical tool for studying CK1-mediated modulation of circadian rhythms
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