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Medchemexpress LLC PF-670462 dihydrochloride | 950912-80-8 | C19H22Cl2FN5 | 5 MG
Supplier: Medchemexpress LLC HY154905MG
PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase (CK1ε and CK1δ) and a potent inhibitor of Wnt/β-catenin signaling. In vivo, it produces robust phase delays in circadian rhythms, affecting gene transcription in the liver, pancreas, and suprachiasmatic nucleus.
- Potent and selective inhibitor of CKIε and CKIδ
- Potent inhibitor of Wnt/β-catenin signaling
- Lower selectivity for EGFR and SAPK2A/p38
- Causes GFP signal redistribution to the cytoplasm
- Produces robust phase delays in circadian rhythms in rats
- Delays rhythmic transcription of Bmal1, Per1, Per2, and Nr1d1 in liver and pancreas
- Delays Nr1d1 and Dbp mRNA expression in the suprachiasmatic nucleus
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