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Apexbio Technology LLC PF-8380 1144035-53-9 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A37205.1
PF-8380 (CAS 1144035-53-9) is a selective inhibitor of autotaxin (ATX) a secreted enzyme with lysophospholipase D activity that converts lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA) As increased local LPA production promotes tumor proliferation and invasion targeting ATX reduces LPA synthesis PF-8380 demonstrates potent ATX inhibition (IC50 2 8 nM) significantly lowering LPA in plasma and tissue in rodent models It reduces Akt activation enhances radiosensitivity and diminishes growth and invasion of glioblastoma cells indicating utility in oncology research focused on ATX-LPA signaling pathways
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