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Medchemexpress LLC PF15 (TFA) | 99.7% | C46H50F3N13O8 | 25 MG
Supplier: Medchemexpress LLC 25MGHY143286A
PF15 TFA is a PROTAC that connects ligands for FLT3 kinase and CRBN. It is a highly selective FLT3-ITD degrader with a DC50 of 76.7 nM. It significantly inhibits the proliferation of FLT3-ITD-positive cells and can down-regulate the phosphorylation of FLT3 and STAT5. It also inhibits tumor growth in mouse models and can be used in the study of leukemia.
- Connects ligands for FLT3 kinase and CRBN
- Highly selective FLT3-ITD degrader
- Has a DC50 of 76.7 nM
- Inhibits proliferation of FLT3-ITD-positive cells
- Down-regulates the phosphorylation of FLT3 and STAT5
- Inhibits tumor growth in mouse models
- Used in the study of leukemia
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