Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 5000089545

Apexbio Technology LLC PFK-015 4382-63-2 10mM (in 1mL DMSO)
SDP

Catalog No. 5000089545
Encompass_Preferred

PFK-015 (CAS 4382-63-2) is a selective inhibitor of 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase 3 (PFKFB3) with an IC50 of 207 nM PFKFB3 regulated by HIF- and activated by oncogenic signaling pathways such as AKT and Ras plays a key role in glycolytic flux and tumor metabolism In cellular assays PFK-015 exhibits cytotoxic effects in lung adenocarcinoma (H522) and leukemia (Jurkat) cell lines suppressing glucose uptake intracellular ATP and F2 6BP levels It promotes apoptosis in Jurkat cells and reduces metastatic spread in a Lewis lung carcinoma mouse model PFK-015 is utilized in cancer research to investigate glycolysis inhibition as a therapeutic strategy

Catalog No. 50-000-89545 Supplier Apexbio Technology LLC Supplier No. B35755.1
May include imposed supplier surcharges.
Add to Cart
Add to Cart

missing translation for 'validMainframeMsg'

PFK-015 (CAS 4382-63-2) is a selective inhibitor of 6-phosphofructo-2-kinase/fructose-2 6-biphosphatase 3 (PFKFB3) with an IC50 of 207 nM PFKFB3 regulated by HIF- and activated by oncogenic signaling pathways such as AKT and Ras plays a key role in glycolytic flux and tumor metabolism In cellular assays PFK-015 exhibits cytotoxic effects in lung adenocarcinoma (H522) and leukemia (Jurkat) cell lines suppressing glucose uptake intracellular ATP and F2 6BP levels It promotes apoptosis in Jurkat cells and reduces metastatic spread in a Lewis lung carcinoma mouse model PFK-015 is utilized in cancer research to investigate glycolysis inhibition as a therapeutic strategy

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.