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Cayman Chemical PG-01037hydrochlorIde 10mg
Supplier: Cayman Chemical 2207910 MG
A selective dopamine D3 receptor antagonist (Kis = 0.7, 93, and 375 nM for HEK293 cells expressing human D3, D2, and D4 receptors, respectively); inhibits quinpirole-induced stimulation of mitogenesis in CHO cells expressing human dopamine D3 receptors (EC50 = 3 nM); reduces progressive-ratio methamphetamine self-administration in rats allowed extended access at 32 mg/kg; reduces loss of dopaminergic neurons in the substantia nigra pars compacta and improves motor performance in the coat-hanger test in a mouse model of MPTP-induced Parkinson's disease
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