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Cayman Chemical PGE2 Substrate 250uL
Supplier: Cayman Chemical 702183250 UL
A PDGFR and FGFR inhibitor (IC50s 5.35 4.6 28 28 and 78 nM for PDGFRa PDGFRB FGFR1 -2 and -3 respectively) selective for these kinases over FGFR4 (IC50 >1000 nM) but also inhibits c-Kit VEGFR2 VEGFR1 and IGF-1R (IC50s 67 33 36 and 75 nM respectively) as well as EGFR BTK Cdk4/cyclin D3 and MET (IC50s 128 198 214 and 396 nM respectively) inhibits the proliferation of MG-63 U2OS MNNG/HOS and Saos-2 cells (IC50s 0.84 0.76 1.36 and 0.72 UM respectively) inhibits the migration and invasion of U87MG and LN-229 cells at 0.3 and 0.5 UM decreases tumor volume and increases survival in a U87MG orthotopic mouse xenograft model 30 mg/kg
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