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System Biosciences LLC pGF-p53-mCMV-EF1α-Puro LentivectorPGREENFIRE-P53-MCMV-EF1A-PURO Virus = 2 x 10^6 IFUs
SDP

Catalog No. NC3357530
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Study oncogenic signaling by co-expressing dscGFP and luciferase in response to p53 activity at p53 transcriptional response elements. These vectors leverage our reliable lentivector technology and save you time—our pre-built signal transduction pathway reporters come as ready-to-package lentivector plasmid*, ready-to-transduce pre-packaged lentivirus, and as a ready-to-study cell line. The pGF-p53-mCMV-EF1α-Puro Lentivector co-expresses a destabilized copepod GFP (dscGFP; 2-hour half-life) and luciferase from p53 transcriptional response elements (TREs) paired with a minimal CMV promoter (mCMV). The mCMV promoter alone delivers negligible expression, but when downstream of p53 TREs, drives expression of dscGFP and luciferase in response to p53 activity. The result is the ability to quantitatively measure p53 activity at p53 TREs by fluorescence and luciferase activity.

Catalog No. NC3357530 Supplier System Biosciences LLC Supplier No. TR200VAP
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Study oncogenic signaling by co-expressing dscGFP and luciferase in response to p53 activity at p53 transcriptional response elements. These vectors leverage our reliable lentivector technology and save you time—our pre-built signal transduction pathway reporters come as ready-to-package lentivector plasmid*, ready-to-transduce pre-packaged lentivirus, and as a ready-to-study cell line. The pGF-p53-mCMV-EF1α-Puro Lentivector co-expresses a destabilized copepod GFP (dscGFP; 2-hour half-life) and luciferase from p53 transcriptional response elements (TREs) paired with a minimal CMV promoter (mCMV). The mCMV promoter alone delivers negligible expression, but when downstream of p53 TREs, drives expression of dscGFP and luciferase in response to p53 activity. The result is the ability to quantitatively measure p53 activity at p53 TREs by fluorescence and luciferase activity.

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