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Apexbio Technology LLC PHA-680632 398493-79-3 200mg
SDP

Catalog No. 5000096796
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PHA-680632 (CAS 398493-79-3) is a small molecule inhibitor targeting Aurora kinases a family of serine/threonine kinases involved in the regulation of mitosis and chromosomal segregation It potently inhibits Aurora A B and C kinases with IC50 values of 27 nM 135 nM and 120 nM respectively PHA-680632 demonstrates considerably less activity against other kinases such as FGFR1 FLT3 LCK PLK1 STLK2 VEGFR2 and VEGFR3 (IC50 390 5500 nM) In cellular assays PHA-680632 suppresses the proliferation of various cancer cell lines including HCT116 A2780 HL60 and HeLa with IC50 values ranging from 0 06 to 7 15 M This compound serves as a valuable tool for investigating Aurora kinase function and evaluating therapeutic strategies targeting mitotic regulation in cancer research

Catalog No. 50-000-96796 Supplier Apexbio Technology LLC Supplier No. A4122200
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PHA-680632 (CAS 398493-79-3) is a small molecule inhibitor targeting Aurora kinases a family of serine/threonine kinases involved in the regulation of mitosis and chromosomal segregation It potently inhibits Aurora A B and C kinases with IC50 values of 27 nM 135 nM and 120 nM respectively PHA-680632 demonstrates considerably less activity against other kinases such as FGFR1 FLT3 LCK PLK1 STLK2 VEGFR2 and VEGFR3 (IC50 390 5500 nM) In cellular assays PHA-680632 suppresses the proliferation of various cancer cell lines including HCT116 A2780 HL60 and HeLa with IC50 values ranging from 0 06 to 7 15 M This compound serves as a valuable tool for investigating Aurora kinase function and evaluating therapeutic strategies targeting mitotic regulation in cancer research

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