Cayman Chemical PHA-767491hydrochlorIde 50mg

Supplier:  Cayman Chemical 1821850 MG

A nucleoside analog and prodrug form of ara-CTP triphosphorylated to ara-CTP by the successive actions of deoxycytidine kinase deoxycytidylate kinase and nucleoside diphosphate kinase inhibits proliferation of HL-60 ML-1 Raji and Jurkat human leukemia cell lines (IC50s 37 17 16 and 72 nM respectively) induces cell cycle arrest at the G0/G1 phase in HL-60 cells at 2.5 and 15 UM reduces tumor growth and increases tumor caspase-3 activity in an MOLM-13 mouse xenograft model at 75 mg/kg per day intraperitoneally increases survival and reduces brain herpesvirus titers in infected rats at 80 and 320 mg/kg subcutaneously

Catalog No. 50-296-8140