Thermo Scientific™ Phadia™ EliA™ Screens for Connective Tissue Disorders

Description

EliA CTD Screen as well as EliA Symphony are intended for the in vitro qualitative measurement of antinuclear IgG antibodies in human serum and plasma as an aid in the clinical diagnosis of systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD), Sjogren's syndrome, scleroderma and polymyositis/dermatomyositis.

• EliA Symphony Wells are coated with human recombinant U1RNP (RNP70, A, C), SS-A/Ro (60 kDa, 52 kDa), SS-B/La, Centromere B, Scl-70 and Jo-1 proteins and native purified Sm proteins
• EliA CTD Screen Wells are coated with the same antigens as EliA Symphony (exception: SmD peptide instead of purified Sm) but additionally it includes double stranded DNA (native purified), Fibrillarin, RNA Pol III, Rib-P, PM-Scl, PCNA, and Mi-2 proteins
• If present in the patient specimen, antibodies bind to their specific antigen
• After washing away non-bound antibodies, enzyme-labeled antibodies against human IgG antibodies (EliA IgG Conjugate) are added to form an antibody-conjugate complex
• After incubation, non-bound conjugate is washed away and the bound complex is incubated with a Development Solution
• After stopping the reaction, the fluorescence in the reaction mixture is measured
• The higher the response value, the more specific IgG is present in the specimen; to evaluate test results, the response for patient sample is compared directly to the response for calibrators

Specifications

• Detectable Analytes: Antinuclear IgG
• Type: EliA™ Symphony
• Quantity: 48 Tests