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Apexbio Technology LLC Phalloidin(Synonyms: Phalloidin, Amanita phalloides toxin, Phallotoxin, Amanitin phalloides toxin, Phalloidine), 1mg, CAS: 17466-45-4.
Supplier: Apexbio Technology LLC B76781
Phalloidin (CAS 17466-45-4) is a cyclic heptapeptide toxin originally isolated from the Amanita phalloides mushroom which specifically binds filamentous actin (F-actin) with high affinity (Kd approximately 20 nM) without binding to monomeric actin (G-actin) By binding directly to F-actin phalloidin stabilizes these filaments and prevents their depolymerization thereby disrupting the dynamic equilibrium essential for normal cytoskeletal processes Conjugates of phalloidin with fluorophores such as FITC or Cy dyes are widely utilized in microscopy-based applications enabling selective and species-independent visualization of F-actin organization in fixed cells permeabilized samples tissue sections and cell-free assays
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