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Sigma Aldrich Fine Chemicals Biosciences Phalloidin Atto 390 suitab
Supplier: Sigma Aldrich Fine Chemicals Biosciences 5055610NMOL
Atto 390 Phalloidin is a novel fluorescent label with a coumarin structure. The dye is intended for application in the area of life science e.g. labeling of DNA RNA or proteins. Characteristic features of the label are high fluorescence quantum yield large Stokes-shift good photostability and low molecular weight.Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind f actin in liver and muscle cells. As a result of binding phalloidin actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action at high dose levels death of mice or rats occurs within 1 or 2 hours.
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