Sigma Aldrich Fine Chemicals Biosciences Phalloidin Atto 565 suitab

Supplier:  Sigma Aldrich Fine Chemicals Biosciences 9407210NMOL

Atto 565 is a novel fluorescent label that belongs to the class of Rhodamine dyes. It shows a strong absorption high fluorescence quantum yield high thermal and photostability and a very little triplet formation. Atto 565 consists of a mixture of two isomers with practically identical optical absorption and emission Phalloidin is a fungal toxin isolated from the poisonous mushroom Amanita phalloides. Its toxicity is attributed to the ability to bind f actin in liver and muscle cells. As a result of binding phalloidin actin filaments become strongly stabilized. Phalloidin has been found to bind only to polymeric and oligomeric forms of actin and not to monomeric actin. The dissociation constant of the actin-phalloidin complex has been determined to be on the order of 3 x 10-8. Phalloidin differs from amanitin in rapidity of action at high dose levels death of mice or rats occurs within 1 or 2 hours. fluorescent conjugates of phalloidin are used to label actin filaments for histolo

Catalog No. 50-290-1242