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Cayman Chemical Phellandrene 100mg
Supplier: Cayman Chemical 33905100 MG
A nonpeptide NK3 antagonist (Ki 1 nM) selective for NK3 over NK1 and NK2 receptors (Kis 144 and 100000 nM respectively in CHO cells expressing recombinant human receptors) inhibits neurokinin B-induced calcium mobilization in HEK293 cells expressing human NK3 receptors (IC50 16.6 nM) inhibits senktide-induced contractions in isolated rabbit iris sphincter muscle (pD2 9.1) reduces senktide-induced head shakes and tail whips in mice from 5-20 mg/kg inhibits senktide-induced wet-dog shakes increases extracellular dopamine and norepinephrine in the medial prefrontal cortex and attenuates haloperidol-induced increases in nucleus accumbens dopamine levels in guinea pigs
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