Medchemexpress LLC Phellodendrine chloride | 104112-82-5 | 377.86 | 5 MG

Supplier:  Medchemexpress LLC HYN07355MG

Phellodendrine chloride is an orally active plant alkaloid with a broad spectrum of biological activities. It is known for its ability to inhibit the proliferation of KRAS-mutated pancreatic cancer cells, mitigate intestinal damage in ulcerative colitis through autophagy activation, and alleviate gouty arthritis. This compound also demonstrates effects in suppressing allergic reactions and protecting against oxidative stress.

• Inhibits proliferation of KRAS-mutated pancreatic cancer cells.
• Promotes autophagy by activating the AMPK/mTOR pathway.
• Alleviates gouty arthritis by inhibiting the IL-6/STAT3 signaling pathway.
• Suppresses allergic reactions by altering MRGPRB3/MRGPRX2 protein conformation.
• Protects zebrafish embryos from oxidative stress by inhibiting the AKT/NF-κB pathway.
• Exhibits anti-major depressive disorder effects by down-regulating CHRM1, HTR1A, and the PI3K/Akt pathway.

Catalog No. 50-004-15772