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Medchemexpress LLC Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-, 1-(dihydrogen phosphate), sodium salt (1:2) | 168555-66-6 | 99.55% | 440.29 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY1744910MM/1ML

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Fosbretabulin disodium is a tubulin destabilizing agent and a Combretastatin A4 proagent. It selectively targets endothelial cells, leading to the regression of nascent tumor neovessels, reduced tumor blood flow, and central tumor necrosis. This compound has demonstrated inhibitory effects on the growth of various cancer cell lines and increases mean arterial blood pressure while decreasing tumor blood flow in vivo.

  • Tubulin destabilizing agent
  • Combretastatin A4 proagent
  • Selectively targets endothelial cells
  • Induces regression of nascent tumor neovessels
  • Reduces tumor blood flow
  • Causes central tumor necrosis
  • Inhibits growth of leukemia P-388, pancreas BXPC-3, neuroblast SK-N-SH, thyroid SW1736, lung-NSC NCI-H460, prostate DU-145, and pharynx FADU
  • Increases mean arterial blood pressure in vivo
  • Decreases tumor blood flow in vivo

Catalog No. 50-003-86671


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