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Medchemexpress LLC Phenol, 3-[[4-(2-pyridinyl)-2-thiazolyl]amino]- | 315702-75-1 | 99.95% | 50 MG
SDP

Supplier:  Medchemexpress LLC HY13103150MG

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KCC-07 is a potent and brain-penetrant MBD2 (methyl-CpG-binding domain protein 2) inhibitor. It prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1), inducing anti-proliferative BAI1/p53/p21 signaling. It exhibits anticancer activity.

  • Clearly inhibited medulloblastomas (MB) cell growth in vitro.
  • Largely abrogated MBD2 binding to the ADGRB1 promoter in BAI1-silent MB cells.
  • Treatment inhibited tumor growth and significantly extended the survival of MB xenografts in athymic nude mice.

Catalog No. 50-003-40204


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