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Medchemexpress LLC Phenol, 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridinyl]- | 2009273-67-8 | 99.9% | 330.38 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY112937100MG

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GNE-6640 is a selective and non-covalent inhibitor of ubiquitin specific peptidase 7 (USP7). It has IC50 values of 0.75 μM for full length USP7, 0.43 μM for USP7 catalytic domain, 20.3 μM for full length USP47, and 0.23 μM for Ub-MDM2.

  • Promotes endogenous MDM2 ubiquitination with Lys48 (K48)-linked polyubiquitin chains.
  • Targets cellular USP7, MDM2, and p53 signaling pathways.
  • Decreases viability of 108 cell lines with IC50 ≤ 10 μM.
  • Can be combined with doxorubicin or cisplatin to enhance USP7 inhibitor efficacy.
  • Induces tumor cell death.
  • Enhances cytotoxicity with chemotherapeutic agents and targeted compounds.

Catalog No. 50-004-39827


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