Medchemexpress LLC Phenol, 4-[[4-(4-chlorophenyl)-2-thiazolyl]amino]- | 312636-16-1 | 99.25% | 302.78 | 200 MG

Supplier:  Medchemexpress LLC HY13822200MG

SKI-II is an orally active and synthetic inhibitor of sphingosine kinase (SK) activity. It is intended for research use only and causes irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation. It inhibits cell proliferation and promotes β-catenin degradation.

• Orally active and synthetic inhibitor of sphingosine kinase (SK) activity
• IC50 values: 78 μM for SK1 and 45 μM for SK2
• Causes irreversible inhibition of SK1 by inducing its lysosomal and/or proteasomal degradation
• Inhibits cell proliferation by suppressing the Wnt/β-catenin signaling pathway
• Promotes the degradation of β-catenin by enhancing Wnt5A
• Shows synergistic effect with DDP in human gastric carcinoma SGC7901/DDP cell line
• Reduces S1P concentrations in plasma in mice with chronic administration
• Reduces tumor growth in mice bearing solid tumor models

Catalog No. 50-003-48621