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Medchemexpress LLC Phenol, 4-(di-1H-indol-3-ylmethyl)- | 151358-47-3 | 98.1% | 338.40 | 10 MG
Supplier: Medchemexpress LLC 10MGHY112055
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. It inhibits cancer cell growth and mTOR signaling, while inducing apoptosis and cellular stress. This compound has been shown to reduce cell proliferation in various cell lines.
- Significantly decreases cell proliferation
- Induces apoptosis and cleavage of caspases 7 and 8
- Inhibits NR4A1-regulated expression of survivin, bcl-2, and EGFR
- Activates AMPKα and inhibits activation of mTOR and downstream kinases
- Decreases expression of β1-integrin protein and mRNA
- Inhibits migration of breast cancer cell lines
- Significantly inhibits tumor growth in an animal model
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