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Medchemexpress LLC Phenol, 4-(di-1H-indol-3-ylmethyl)- | 151358-47-3 | 98.1% | 338.40 | 25 MG
Supplier: Medchemexpress LLC 25MGHY112055
DIM-C-pPhOH is a nuclear receptor 4A1 (NR4A1) antagonist. It inhibits cancer cell growth and mTOR signaling, and induces apoptosis and cellular stress. It reduces cell proliferation with IC50 values of 13.6 μM and 13.0 μM for ACHN cells and 786-O cells.
- Nuclear receptor 4A1 (NR4A1) antagonist
- Inhibits cancer cell growth and mTOR signaling
- Induces apoptosis and cellular stress
- Reduces cell proliferation in ACHN and 786-O cells
- Inhibits NR4A1-regulated expression (survivin, bcl-2, EGFR)
- Induces sestrin 2, activates AMPKα, inhibits mTOR and downstream kinases
- Decreases β1-integrin protein, mRNA, and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells
- Inhibits migration of MDA-MB-231 and SKBR3 cells
- Significantly inhibits tumor growth in male athymic nude mice (ACHN cells)
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