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Medchemexpress LLC Phenoxybenzamine hydrochloride | 63-92-3 | 99.5% | 1 G
Supplier: Medchemexpress LLC HYB0431A1G
Phenoxybenzamine hydrochloride is a nonselective, irreversible, orally active α-adrenoceptor antagonist. It is primarily used in research for hypertension, particularly that caused by pheochromocytoma, and has also demonstrated antitumor activity.
- Inhibits proliferation of U251 and U87MG cells.
- Inhibits migration and invasion of U251 and U87MG cells.
- Activates LINGO-1 and inhibits the TrkB-Akt pathway.
- Prevents hippocampal cell death after oxygen glucose deprivation.
- Demonstrates anti-tumorigenic effect in nude mice with U87MG tumors.
- Exhibits neuroprotective properties in a rat model of severe traumatic brain injury.
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