Apexbio Technology LLC Phenyl sulfate 937-34-8 25mg

Supplier:  Apexbio Technology LLC B605025

Phenyl sulfate (CAS 937-34-8) is a protein-bound uremic solute implicated in oxidative stress-related cellular injury It accumulates in patients with chronic kidney disease (CKD) inducing reactive oxygen species generation and diminishing intracellular glutathione levels Studies using porcine renal tubular cells demonstrated that phenyl sulfate enhances vulnerability to oxidative damage significantly amplifying hydrogen peroxide-induced cytotoxicity In murine models with diabetic kidney disease (KKAy mice on high-fat diets) phenyl sulfate administration intensified albuminuria and structural renal damage including podocyte effacement and basement membrane alterations Consequently phenyl sulfate serves as a biomarker in CKD research useful in assessing interventions targeting protein-bound uremic toxins

Catalog No. 50-000-63530