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Apexbio Technology LLC Phenylephrine HCl 61-76-7 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B13445.1
Phenylephrine HCl (CAS 61-76-7) is a selective agonist of 1-adrenergic receptors a class of G protein-coupled receptors that mediate the effects of endogenous catecholamines such as norepinephrine and epinephrine Comparative studies indicate phenylephrine displays significant subtype selectivity with inhibitory pKi values of 4 87 4 70 and 5 86 for 1B- 1C- and 1A/D-adrenergic receptors respectively and agonist potencies (pEC50) of 6 47 6 77 and 7 01 for these subtypes In preclinical models phenylephrine has been shown to enhance alveolar fluid clearance and promote pulmonary edema absorption in ventilator-induced lung injury in a dose-dependent manner This compound is widely utilized in studies of adrenergic receptor signaling and pulmonary physiology
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