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Medchemexpress LLC PhiKan 083 hydrochlo | 1050480-30-2 | 99.3% | 274.79 | 10 MG
Supplier: Medchemexpress LLC HY108637A50MG
PhiKan 083 hydrochloride is a carbazole derivative that functions as a p53 Y220C stabilizer. It binds to the surface cavity of the Y220C (a p53 mutant) with a Kd of 167 μM and demonstrates a relative binding affinity (Kd) of 150 μM in Ln229 cells. This compound has been shown to slow down the thermal denaturation rate of p53 Y220C.
- Binds to the surface cavity of p53 Y220C mutant.
- Stabilizes p53 Y220C.
- Exhibits a Kd of 167 μM for p53 Y220C.
- Shows a relative binding affinity of 150 μM in Ln229 cells.
- Slows the thermal denaturation rate.
- Reduces cell viability of engineered Ln229 cell variants.
- Enhances pro-apoptotic activity in Ln229 cells when combined with NSC 123127.
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