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Medchemexpress LLC PhiKan 083 hydrochloride | 1050480-30-2 | 99.27% | 274.79 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY108637A

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PhiKan 083 hydrochloride is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM, and a relative binding affinity (Kd) of 150 μM in Ln229 cells.

  • Binds to the surface cavity and stabilizes Y220C (a p53 mutant)
  • Kd of 167 μM (p53-Y220C)
  • Relative binding affinity (Kd) of 150 μM in Ln229 cells
  • Slows down its thermal denaturation rate
  • Reduces the cell viability of engineered variants of Ln229 cells (125 μM, 48 hours)
  • Enhances pro-apoptotic activity in all variants of Ln229 cells (p53wt, p53Y220C, p53G245S, p53R282W) when combined with NSC 123127 (1 μM)

Catalog No. 50-003-47464


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