PKC activator. PKC activator (10-100 ng/ml). Most commonly used phorbol ester. Causes an extremely wide range of effects in cells and tissues. Very potent mouse skin tumor promoter. Inhibits apoptosis induced by Fas, but induces apoptosis in HL-60 promyelocytic leukemia cells. Formula: C36H56O8. MW: 616.8. CAS Number: 16561-29-8. Purity: ≥99% (HPLC, TLC). Appearance: Colorless amorphous film or foam. Solubility: Soluble in DMSO (25mg/ml), 100% ethanol (25mg/ml), acetone, ether or dimethyl formamide; almost insoluble in aqueous buffers. Use/Stability: Dissolve in an organic solvent prior to dilution into aqueous buffers. Add calculated volume of organic solvent to vial to prepare concentrated stock solution. Intermediate dilutions into the same organic solvent are recommended prior to final dilution into aqueous buffer. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. Long Term Storage: -20°C