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Cayman Chemical Phosphate Buffer 2.5ea
Supplier: Cayman Chemical 4000322.5 EA
A chymase inhibitor (IC50s 4 and 3 nM for the human and hamster enzyme respectively) reduces isoprenaline-induced cardiac fibrosis in hamsters at 1 3 and 10 mg/kg inhibits decreases in left ventricular ejection fraction and increases in left ventricular end-systolic volume decreases in plasma levels of nt-proBNP TGF-B1 and TNF-a as well as the levels of interstitial fibrosis and the cross-sectional area of myocytes in a coronary microembolism-induced canine model of heart failure at 2 and 5 mg/kg per day
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