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Cayman Chemical PhosphatIdylglyceroleggs 50mg

Supplier: Cayman Chemical 2584650 MG

A membrane-permeable blocker of IKCa1/KCa3.1 (Kds 20 and 25 nM for the cloned and native channel in COS-7 cells and human T lymphocytes respectively) 200- to 1500-fold selective for IKCa1 over Kv (Kv1.1-Kv1.5 Kv3.1 Kv4.2) Kir2.1 BK/KCa1.1 SKCa (rSKCa2 hSKCa2 hSKCa3) native SKCa/KCa2 and CRAC in Jurkat T cells as well as sodium and chloride channels suppresses reactivation of human-derived T lymphocytes stimulated with anti-CD3 antibody (mean EC50s 295 and 910 nM from sensitive and less sensitive human donors respectively) inhibits proliferation of human endometrial cancer cells and induces cell cycle arrest at the G0/G1 phase inhibits proliferation of LNCaP and PC3 prostate cancer cells inhibits proliferation induced by epidermal growth factor (EGF) in smooth muscle A7r5 cells (IC50 8 nM) reduces intimal hyperplasia by approximately 40 after 1 2 and 6 weeks in a rat model of balloon catheter injury when administered at a dose of 120 mg/kg per day pretreatment
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