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BIOHIPPO Phospho-4E-BP1 Thr37/46 rAb
Supplier: BIOHIPPO BHA21821341
U-Blot Pan Phospho-4E-BP1 (Thr37/46) Rabbit mAb is a Rabbit-derived recombinant monoclonal antibody (clone W-R32) that specifically recognizes Phospho-4E-BP1 (Thr37/46) a phosphorylation modification at Thr37/46 It shows reactivity with Human Validated applications include WB Recommended dilutions WB 1500-11000 Purified by protein a Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) is a repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex The 4E-BP1 hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E leading to repress translation In contrast hyperphosphorylated form dissociates from EIF4E allowing interaction between EIF4G1/EIF4G3 and EIF4E leading to initiation of translation Besides 4E-BP1 mediates the regulation of protein translation by hormones growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways Supplied as 100 uL
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