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ABclonal Technology Phospho-MDM2-S166 Rabbit mAb
Supplier: ABclonal Technology AP130820UL
This gene encodes a nuclear-localized E3 ubiquitin ligase The encoded protein can promote tumor formation by targeting tumor suppressor proteins such as p53 for proteasomal degradation This gene is itself transcriptionally-regulated by p53 Overexpression or amplification of this locus is detected in a variety of different cancers There is a pseudogene for this gene on chromosome 2 Alternative splicing results in a multitude of transcript variants many of which may be expressed only in tumor cells
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