ABclonal Technology Phospho-NF-B p105-S932

Supplier:  ABclonal Technology AP135520UL

This gene encodes a 105 kD protein that is processed by the 26S proteasome into a 50 kD protein The 105 kD protein acts as a Rel protein-specific transcription inhibitor while the 50 kD protein is a DNA-binding subunit of the NF-kappa-B (NFKB) complex NFKB activated by stimuli like cytokines UV irradiation and bacterial or viral products regulates various biological functions Once activated NFKB translocates to the nucleus to stimulate gene expression Inappropriate NFKB activation is linked to inflammatory diseases while its inhibition can disrupt immune cell development and delay cell growth NFKB also regulates the early response to viral infections Alternative splicing generates multiple isoforms including proteolytically processed variants

Catalog No. 50-000-13998