ABclonal Technology Phospho-NF-B2-S866/S870

Supplier:  ABclonal Technology AP1391100UL

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB) The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner The p100 full-length protein is co-translationally processed into a p52 active form Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas some of which may result in the formation of fusion proteins There is a pseudogene for this gene on chromosome 18 Alternative splicing results in multiple transcript variants

Catalog No. 50-000-14049