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ABclonal Technology Phospho-NFKB1-S337 Rabbit mAb
Supplier: ABclonal Technology AP152820UL
This gene encodes a 105 kD protein that undergoes cotranslational processing by the 26S proteasome to form a 50 kD DNA-binding subunit of the NF-kappa-B (NFKB) complex NFKB is a transcription regulator activated by stimuli such as cytokines UV irradiation and bacterial or viral products Upon activation NFKB translocates to the nucleus regulating genes involved in diverse biological functions Dysregulated NFKB activation is linked to inflammatory diseases while its inhibition can affect immune cell development and growth NFKB plays a key role in the immediate-early response to viral infection Alternative splicing results in multiple isoforms some of which are proteolytically processed
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