ABclonal Technology Phospho-NFKB1-S337 Rabbit

Supplier:  ABclonal Technology AP0125PM20UL

This gene encodes a 105 kD protein that is processed by the 26S proteasome into a 50 kD protein The 105 kD protein inhibits Rel protein-specific transcription while the 50 kD protein is a DNA-binding subunit of the NF-kappa-B (NFKB) complex NFKB is activated by various stimuli like cytokines free radicals UV irradiation and pathogens Once activated NFKB translocates to the nucleus to regulate genes involved in many biological functions Dysregulation of NFKB activation is linked to inflammatory diseases immune cell development issues and impaired cell growth NFKB is key in the immediate-early response to viral infections Alternative splicing produces multiple isoforms including one that undergoes proteolytic processing

Catalog No. 50-000-13832