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ABclonal Technology Phospho-PTEN-S380/T382/T383
Supplier: ABclonal Technology AP1346100UL
This gene encodes a tumor suppressor protein that is frequently mutated in cancers It functions as a phosphatidylinositol-3 4 5-trisphosphate 3-phosphatase with a tensin-like and catalytic domain similar to dual specificity protein tyrosine phosphatases Unlike typical tyrosine phosphatases it specifically dephosphorylates phosphoinositide substrates and negatively regulates phosphatidylinositol-3 4 5-trisphosphate levels thereby inhibiting the AKT signaling pathway A longer isoform produced through a non-canonical initiation site is associated with the mitochondrial inner membrane and may regulate mitochondrial energy metabolism A pseudogene of this gene is located on chromosome 9 Alternative splicing and multiple translation start codons result in various isoforms
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