U-Blot Phospho-(Ser/Thr) PDK1 Docking Motif Mouse mAb is a Mouse-derived recombinant monoclonal antibody (clone W-R31) that specifically recognizes Phospho-(Ser/Thr) PDK1 Docking Motif a phosphorylation modification at Serine/Threonine residues in the PDK1 docking motif It shows reactivity with Human Validated applications include WB Recommended dilutions WB 1500-11000 Purified by protein a Many critical protein kinases can be regulated by phosphorylation at a specific serine or threonine in a hydrophobic motif For example Akt a kinase that regulates cell survival is activated by phosphorylation at Ser473 a site preceded by Phe at -4 and -1 and followed by Tyr at 1 RSK2 p70 S6 kinase and certain PKC isoforms also contain a similar consensus phosphorylation motif Phosphorylation of these motifs is required for binding to 3-phosphoinositide dependent kinase 1 (PDK1) Supplied as 100 uL