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ABclonal Technology Phospho-Smad2-S465/S467
Supplier: ABclonal Technology AP1342100UL
This gene encodes a protein from the SMAD family which functions as a signal transducer and transcriptional modulator in various signaling pathways It mediates the transforming growth factor (TGF)-beta signal regulating cell proliferation apoptosis and differentiation The protein interacts with the SMAD anchor for receptor activation (SARA) and is phosphorylated by TGF-beta receptors leading to its dissociation from SARA and association with SMAD4 This interaction is crucial for nuclear translocation where the protein binds to target promoters and forms a transcription repressor complex It can also be phosphorylated by activin receptor kinase to mediate activin signals Alternative splicing results in different transcript variants
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