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Medchemexpress LLC Phosphonoacetic acid | 4408-78-0 | 98.0% | 1 ML
Supplier: Medchemexpress LLC HY12874410MM/1ML
Phosphonoacetic acid is an endogenous metabolite and an antiviral agent. It exhibits activity against orthopoxviruses and herpes viruses. It can inhibit HSV DNA synthesis and virus-specific DNA polymerase activity, also affecting the synthesis of late viral proteins.
- Active against orthopoxviruses and herpes viruses.
- Inhibits HSV DNA synthesis.
- Inhibits virus-specific DNA polymerase activity.
- Affects the synthesis of late viral proteins.
- IC50 & target: DNA polymerase, human endogenous metabolite.
- Cellular effect: Vero CC50: 3500 μM, Vero ED50: 240 μM.
- Inhibits viral growth and DNA synthesis in HSV-1-infected BHK-21 cells.
- Shows protective effect in rabbit skin lesion model infected with orthopoxvirus.
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