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AdipoGen Phosphoramidon disodium salt
Supplier: AdipoGen AGCP37008M025
Chemical. CAS 164204-38-0. Formula C23H32N3O10P . 2Na. Molecular Weight 541.5 . 46.0. Phosphoramidon is a potent, reversible and competitive inhibitor of multiple soluble and membrane-bound zinc metalloproteases, particularly gluzincins, such as neutral endopeptidase NEP Neprilysin CD10 EC 3.4.24.11 Ki = 2nM, NEP2 Neprilysin-2 Ki ~ 2nM, or endothelin-converting enzyme ECE IC50 = 0.68µM. It inhibits the thermostable neutral metalloproteinase enzyme thermolysin and the integral membrane protein zinc metalloprotease ZMPSTE24. It has little or no effect on a variety of other proteases, including trypsin, papain, chymotrypsin, pepsin and angiotensin-converting enzyme. Shows anti-inflammatory, anti-neurodegenerative and cardioprotective properties. Blocks through NEP degradation of amyloid beta peptides and increases Abeta levels in rodents, indicating that abnormal amyloid processing in Alzheimers disease may be carried out by a metalloendopeptidase.
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