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Cayman Chemical PhosphorScent Oxygen Probe 1ea
Supplier: Cayman Chemical 6008011 EA
A TTR kinetic stabilizer selectively binds to wild-type TTR and TTRV122I with negative cooperativity (Kd1s 4.8 and 6.2 nM respectively Kd2s 314 and 139 nM respectively) over COX-1 COX-2 and the thyroid hormone nuclear receptor (IC50s >10 UM for all) inhibits pH-induced amyloidogenesis of wild-type TTR and TTRV122I indicating tetramer stabilization stabilizes TTRV122I in serum isolated from patients with familial amyloid cardiomyopathy at 10 UM
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